Tetracycline HCl Drug Study

Friday, February 20, 2009

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.


Tetracycline hydrochloride

Brand Name: Apo-Tetra (CAN), Novo-Tetra (CAN), Nu-Tetra (CAN), Panmycin, Sumycin, Tetracap, Tetracyn, Tetralan, Topicycline

Pregnancy Category D, Pregnancy Category B (Topicycline only)

Drug classes: Antibiotic, Tetracycline

Therapeutic actions

Bacteriostatic: inhibits protein synthesis of susceptible bacteria, preventing cell replication.

Indications

Systemic administration

· Infections caused by rickettsiae; Mycoplasma pneumoniae; agents of psittacosis, ornithosis, lymphogranuloma venereum and granuloma inguinale; Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Yersinia tularensis, Bartonella bacilliformis, Bacteroides, Vibrio cholerae, Campylobacter fetus, Brucella, Escherichia coli, Enterobacter aerogenes, Shigella, Acinetobacter calcoaceticus, Haemophilus influenzae, Klebsiella, Streptococcus pneumoniae

· When penicillin is contraindicated, infections caused by Neisseria gonorrhoeae, Treponema pallidum, Treponema pertenue, Listeria monocytogenes, Clostridium, Bacillus anthracis, Fusobacterium fusiforme, Actinomyces, Neisseria meningitidis

· Adjunct to amebicides in acute intestinal amebiasis

· Treatment of acne (oral)

· Uncomplicated urethral, endocervical or rectal infections in adults caused by Chlamydia trachomatis

· Instilled in a chest tube, unlabeled use: pleural sclerosing agent in malignant pleural effusions

· Treatment of trachoma

Contraindications

Systemic administration and dermatologic solution

· Contraindicated with allergy to any of the tetracyclines; allergy to tartrazine (in 250-mg capsules of Panmycin); pregnancy (toxic to the fetus); lactation (causes damage to the teeth of infant).

Adverse effects

Phototoxic reactions, rash, exfoliative dermatitis

Discoloring and inadequate calcification of primary teeth of fetus if used by pregnant women, discoloring and inadequate calcification of permanent teeth if used during period of dental development, fatty liver, liver failure, anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, esophageal ulcers

Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, leukocytosis, leukopenia

Reactions from urticaria to anaphylaxis, including intracranial hypertension

Superinfections, local irritation at parenteral injection sites

Drug Interactions:

· Decreased absorption with calcium salts, magnesium salts, zinc salts, aluminum salts, bismuth salts, iron, urinary alkalinizers, food, dairy products, charcoal

· Increased digoxin toxicity

· Increased nephrotoxicity with methoxyflurane

· Decreased effectiveness of hormonal contraceptives, though rare, has been reported with a risk of breakthrough bleeding or pregnancy

· Decreased activity of penicillins

Nursing considerations

· Administer oral medication on an empty stomach, 1 hr before or 2–3 hr after meals. Do not give with antacids. If antacids must be used, give them 3 hr after the dose of tetracycline.

· Culture infection before beginning drug therapy.

· Do not administer during pregnancy; drug is toxic to the fetus.

· Do not use outdated drugs; degraded drug is highly nephrotoxic and should not be used.

· Do not give oral drug with meals, antacids, or food.

· Arrange for regular renal function tests with long-term therapy.

· Use topical preparations of this drug only when clearly indicated. Sensitization from the topical use may preclude its later use in serious infections. Topical preparations containing antibiotics that are not ordinarily given systemically are preferable.

1 comments:

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