Ofloxacin Drug Study

Friday, February 20, 2009

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.

Ofloxacin


Brand Name: Floxin, Ocuflox


Pregnancy Category C


Drug classes: Antibiotic, Fluoroquinolone


Therapeutic actions

Bactericidal; interferes with DNA replication in susceptible gram-positive and gram-negative bacteria, preventing cell reproduction.


Indications

· Lower respiratory tract infections caused by Haemophilus influenzae, Streptococcus pneumoniae

· Acute, uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae, nongonococcal urethritis, and cervicitis due to Chlamydia trachomatis, mixed infections due to both

· Skin and soft tissue infections due to Staphylococcus aureus, Staphylococcus pyogenes, Proteus mirabilis

· Urinary tract infections due to Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa

· Primary treatment of PID (oral)

· Prostatitis due to E. coli

· Treatment of ocular infections caused by susceptible organisms (ophthalmic solution)

· Orphan drug use: treatment of bacterial corneal ulcers

· Otic: otitis externa, chronic suppurative otitis media, acute otitis media


Contraindications

· Contraindicated with allergy to fluoroquinolones, pregnancy, lactation.


Adverse effects

Headache, dizziness, insomnia, fatigue, somnolence, depression, blurred vision,

Nausea, vomiting, dry mouth, diarrhea, abdominal pain, Elevated BUN, AST, ALT, serum creatinine and alkaline phosphatase; decreased WBC, neutrophil count, Hct,

Fever, rash, photosensitivity


Drug Interactions:

· Decreased therapeutic effect with iron salts, zinc, sucralfate

· Decreased absorption with antacids


Nursing considerations

· Arrange for culture and sensitivity tests before beginning therapy.

· Continue therapy for 2 days after the signs of infection have disappeared.

· Administer oral drug 1 hr before or 2 hr after meals with a glass of water.

· Ensure that patient is well hydrated.

· Administer antacids at least 2 hr after dosing.

· Monitor clinical response; if no improvement is seen or a relapse occurs, repeat culture and sensitivity

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