Naproxen Drug Study

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.

Naproxen

Brand Name: Apo-Naproxen (CAN), EC-Naprosyn, Naprelan, Naprosyn, Naxen (CAN), Novo-Naprox (CAN), naproxen sodium, Aleve, Anaprox, Anaprox DS, Apo-Napro-Na (CAN), Synflex (CAN)

Pregnancy Category B (first and second trimesters), Pregnancy Category D (third trimester)

Drug classes: Nonsteroidal anti-inflammatory drug (NSAID), Analgesic (non-narcotic)

Therapeutic actions

Analgesic, anti-inflammatory, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.

Indications

· Mild to moderate pain

· Treatment of primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, acute gout

· OTC use: temporary relief of minor aches and pains associated with the common cold, headache, toothache, muscular aches, backache, minor pain of arthritis, pain of menstrual cramps, reduction of fever

· Treatment of juvenile arthritis (naproxen only)

Contraindications

· Contraindicated with allergy to naproxen, salicylates, other NSAIDs; pregnancy; lactation.

Adverse effects

Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthalmic effects

Rash, pruritus, sweating, dry mucous membranes, stomatitis

Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence

Dysuria, renal impairment, including renal failure, interstitial nephritis, hematuria

Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression, menorrhagia

Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis

Peripheral edema, anaphylactoid reactions to anaphylactic shock

Drug Interactions:

· Increased serum lithium levels and risk of toxicity with naproxen

Nursing considerations

· Give with food or after meals if GI upset occurs.

· Arrange for periodic ophthalmologic examination during long-term therapy.

· Institute emergency procedures if overdose occurs: gastric lavage, induction of emesis, supportive therapy.