Neomycin Drug Study

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.

Neomycin sulfate

Brand Name: Mycifradin, Neo-fradin, Neo-Tabs, Mycifradin (CAN), Myciguent

Pregnancy Category D

Drug class: Aminoglycoside

Therapeutic actions

Bactericidal: inhibits protein synthesis in susceptible strains of gram-negative bacteria; functional integrity of bacterial cell membrane appears to be disrupted, causing cell death. Due to poor PO absorption, oral neomycin is used to suppress GI bacterial flora.

Indications

· Preoperative suppression of GI bacterial flora (oral)

· Hepatic coma to reduce ammonia-forming bacteria in the GI tract (oral)

· Infection prophylaxis in minor skin wounds and treatment of superficial skin infections due to susceptible organisms (topical dermatologic preparations)

Contraindications

· Contraindicated with allergy to aminoglycosides, intestinal obstruction, pregnancy, lactation.

Adverse effects

Palpitations, hypotension, hypertension, Hepatic toxicity, nausea, vomiting, anorexia, weight loss, stomatitis, increased salivation, Nephrotoxicity, Leukemoid reaction, agranulocytosis, granulocytosis, leukopenia, leukocytosis, thrombocytopenia, eosinophilia, pancytopenia, anemia, hemolytic anemia, increased or decreased reticulocyte count, electrolyte disturbances, Hypersensitivity reactions: purpura, rash, urticaria, exfoliative dermatitis, itching, Pain, irritation, Fever, apnea, splenomegaly, joint pain, superinfection

Drug Interactions:

· Increased ototoxic, nephrotoxic, neurotoxic effects with other aminoglycosides, potent diuretics

· Increased neuromuscular blockade and muscular paralysis with anesthetics, nondepolarizing neuromuscular blocking drugs, succinylcholine, citrate-anticoagulated blood

· Potential inactivation of both drugs if mixed with beta-lactam–type antibiotics

· Increased bactericidal effect with penicillins, cephalosporins, carbenicillin, ticarcillin

· Decreased absorption and therapeutic effects of digoxin

Nursing considerations

· Ensure that the patient is well hydrated.

· Report hearing changes, dizziness, severe diarrhea.