Medroxyprogesterone acetate
Brand Name: Depo-Provera
Pregnancy Category X
Drug classes: Hormone, Progestin, Antineoplastic
Therapeutic actions
Progesterone derivative; endogenous progesterone transforms proliferative endometrium into secretory endometrium; inhibits the secretion of pituitary gonadotropins, which prevents follicular maturation and ovulation; inhibits spontaneous uterine contraction.
Indications
· Reduction of endometrial hyperplasia in postmenopausal women
· Treatment of secondary amenorrhea (oral)
· Abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology (oral)
· Adjunctive therapy and palliation of inoperable, recurrent, and metastatic endometrial carcinoma or renal carcinoma (parenteral)
· Unlabeled use for depot form: long-acting contraceptive, treatment of breast cancer
Contraindications
· Contraindicated with allergy to progestins; thrombophlebitis, thromboembolic disorders, cerebral hemorrhage or history of these conditions; hepatic disease, carcinoma of the breast, ovaries, or endometrium, undiagnosed vaginal bleeding, missed abortion; pregnancy (fetal abnormalities, including masculinization of the female fetus have been reported); lactation.
Adverse effects
Sudden, partial, or complete loss of vision; proptosis, diplopia, migraine, precipitation of acute intermittent porphyria, mental depression, pyrexia, insomnia, somnolence, nervousness, fatigue
Thrombophlebitis, cerebrovascular disorders, retinal thrombosis, pulmonary embolism, thromboembolic and thrombotic disease, increased BP
Rash with or without pruritus, acne, melasma or chloasma, alopecia, hirsutism, photosensitivity, pruritus, urticaria
Cholestatic jaundice, nausea
Breakthrough bleeding, spotting, change in menstrual flow, amenorrhea, changes in cervical erosion and cervical secretions, breast tenderness and secretion
Fluid retention, edema, increase or decrease in weight, decreased glucose tolerance
Nursing considerations
· Arrange for pretreatment and periodic (at least annual) history and physical, which should include BP, breasts, abdomen, pelvic organs, and a Pap smear.
· Alert patient before therapy to prevent pregnancy and to have frequent medical follow-ups.
· Discontinue medication and consult physician if sudden, partial, or complete loss of vision occurs; if papilledema or retinal vascular lesions are present, discontinue drug.
· Discontinue medication and consult physician at the first sign of thromboembolic disease (leg pain, swelling, peripheral perfusion changes, shortness of breath).
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