Benazepril hydrochloride Drug Study

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.

Benazepril hydrochloride

Brand Name: Lotensin

Pregnancy Category C (first trimester), Pregnancy Category D (second, third trimesters)

Drug classes: Antihypertensive, Angiotensin-converting enzyme (ACE) inhibitor

Therapeutic actions

Blocks ACE from converting angiotensin I to angiotensin II, a potent vasoconstrictor, leading to decreased BP, decreased aldosterone secretion, a small increase in serum potassium levels, and sodium and fluid loss; increased prostaglandin synthesis also may be involved in the antihypertensive action.

Indications

· Treatment of hypertension alone or in combination with thiazide-type diuretics

Contraindications

· Contraindicated with allergy to benazepril or other ACE inhibitors.

Adverse effects

Angina pectoris, hypotension in salt/volume depleted patients, palpitations, rash, pruritus, diaphoresis, flushing, Nausea, abdominal pain, vomiting, constipation, Cough, asthma, bronchitis, dyspnea, sinusitis, Angioedema, impotence, decreased libido, asthenia, myalgia, arthralgia

Drug Interactions

· Increased risk of hypersensitivity reactions with allopurinal

· Increased coughing with capsaicin

· Decreased antihypertensive effects with indomethacin

· Increased lithium levels and neurotoxicity may occur if combined

· Increased risk of hyperkalemia with potassium-sparing diuretics or potassium supplements

Nursing considerations

· Alert surgeon: Note use of benazepril on patient's chart; the angiotensin II formation subsequent to compensatory renin release during surgery will be blocked; hypotension may be reversed with volume expansion.

· Monitor patient for possible fall in BP secondary to reduction in fluid volume (excessive perspiration and dehydration, vomiting, diarrhea) because excessive hypotension may occur.

· Reduce dosage in patients with impaired renal function.