Lansoprazole Drug Study

Friday, February 20, 2009

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.


Lansoprazole


Brand Name: Prevacid


Pregnancy Category B


Drug classes: Antisecretory agent, Proton pump inhibitor



Therapeutic actions

Gastric acid-pump inhibitor: suppresses gastric acid secretion by specific inhibition of the hydrogen/potassium ATPase enzyme system at the secretory surface of the gastric parietal cells; blocks the final step of acid production.



Indications


· Short-term treatment of active duodenal ulcer (<>

· Short-term treatment of gastroesophageal reflux disease: severe erosive esophagitis; poorly responsive symptomatic gastroesophageal reflux disease (<>

· Treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome, multiple adenomas, systemic mastocytosis)--long-term therapy

· Maintenance therapy for healing of erosive esophagitis, duodenal ulcers

· Eradication of Helicobacter pylori infection in patients with active or recurrent duodenal ulcers in combination with clarithromycin and amoxicillin

· Short-term treatment of symptomatic gastroesophageal reflux disease and erosive esophagitis in children 1–11 yr



Contraindications


· Contraindicated with hypersensitivity to lansoprazole or any of its components.



Adverse effects


Headache, dizziness, asthenia, vertigo, insomnia, anxiety, paresthesias, dream abnormalities, Rash, inflammation, urticaria, pruritus, alopecia, dry skin, acne,

Diarrhea, abdominal pain, nausea, vomiting, constipation, dry mouth, URI symptoms, cough, epistaxis, Gastric cancer in preclinical studies, back pain, fever



Drug Interactions:


· Decreased serum levels if taken concurrently with sucralfate

· Decreased serum levels of ketoconazole, theophylline when taken with lansoprazole



Nursing considerations


· Administer before meals. Caution patient to swallow capsules whole, not to open, chew, or crush. If patient has difficulty swallowing, open capsule and sprinkle granules on apple sauce, Ensure, yogurt, cottage cheese, or strained pears; for NG tube, mix granules from capsule with 40 mL apple juice and inject through tube, flush tube with additional apple juice; or granules for oral suspension can be added to 30 mL water, stir well, and have patient drink immediately.

· Arrange for further evaluation of patient after 4 wk of therapy for acute gastroreflux disorders if symptomatic improvement does not rule out gastric cancer, which did occur in preclinical studies.


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