Nystatin Drug Study

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.

Nystatin

Pregnancy Category C

Drug class: Antifungal

Therapeutic actions

Fungicidal and fungistatic: binds to sterols in the cell membrane of the fungus with a resultant change in membrane permeability, allowing leakage of intracellular components and causing cell death.

Indications

· Treatment of oropharyngeal candidiasis (oral)

· Treatment of oral candidiasis (oral suspension, troche)

· Local treatment of vaginal candidiasis (moniliasis; vaginal)

· Treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other Candida species (topical applications)

Contraindications

· Contraindicated with allergy to nystatin or components used in preparation.

Adverse effects

Diarrhea, GI distress, nausea, vomiting

Nursing considerations

· Culture fungus before therapy.

· Have patient retain oral suspension in mouth as long as possible before swallowing. Pain suspension on each side of the mouth. Continue local treatment for at least 48 hr after clinical improvement is noted.

· Prepare nystatin in the form of frozen flavored popsicles to improve oral retention of the drug for local application.

· Administer nystatin troche orally for the treatment of oral candidiasis; have patient dissolve 1–2 tablets in mouth.

· Insert vaginal suppositories high into the vagina. Have patient remain recumbent for 10–15 min after insertion. Provide sanitary napkin to protect clothing from stains.

· Cleanse affected area before topical application unless otherwise indicated.

· Monitor response to drug therapy. If no response is noted, arrange for further cultures to determine causative organism.

· Ensure that patient receives the full course of therapy to eradicate the fungus and to prevent recurrence.

· Discontinue topical or vaginal administration if rash or sensitivity occurs.