Ranitidine Drug Study

In making a Drug Study, the following elements must be present: Generic Name and the Brand name (not all brands, just the brand used by the patient), Action, Indication, Pregnancy Category, Drug Classification, and Contraindication, Adverse Effect, Drug interaction and Nursing Consideration/Intervention…. Most clinical instructors preferred this to be in a long bond paper in printed or handwritten with paper in landscape.

Ranitidine hydrochloride

Brand Name: Alti-Ranitidine (CAN), Novo-Ranidine (CAN), Nu-Ranit (CAN), Zantac, Zantac EFFERdose, Zantac GELdose, Zantac 75

Pregnancy Category B

Drug class: Histamine₂ (H₂) antagonist

Therapeutic actions

Competitively inhibits the action of histamine at the histamine₂ (H₂) receptors of the parietal cells of the stomach, inhibiting basal gastric acid secretion and gastric acid secretion that is stimulated by food, insulin, histamine, cholinergic agonists, gastrin, and pentagastrin.

Indications

· Short-term treatment of active duodenal ulcer

· Maintenance therapy for duodenal ulcer at reduced dosage

· Short-term treatment of active, benign gastric ulcer

· Short-term treatment of gastroesophageal reflux disease

· Pathologic hypersecretory conditions (eg, Zollinger-Ellison syndrome)

· Treatment of erosive esophagitis

· Treatment of heartburn, acid indigestion, sour stomach

Contraindications

· Contraindicated with allergy to ranitidine, lactation.

· Use cautiously with impaired renal or hepatic function.

Adverse effects

Headache, malaise, dizziness, somnolence, insomnia, vertigo, Tachycardia, bradycardia, PVCs (rapid IV administration), Rash, alopecia, Constipation, diarrhea, nausea, vomiting, abdominal pain, hepatitis, increased ALT levels, Gynecomastia, impotence or decreased libido, Leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, Pain at IM site, local burning or itching at IV site, Arthralgias

Drug Interactions:

· Increased effects of warfarin, TCAs

· Decreased effectiveness of diazepam

· Decreased clearance and possible increased toxicity of lidocaine, nifedipine

Nursing considerations

· Administer oral drug with meals and at bedtime.

· Decrease doses in renal and liver failure.

· Provide concurrent antacid therapy to relieve pain.

· Administer IM dose undiluted, deep into large muscle group.

· Arrange for regular follow-up, including blood tests, to evaluate effects.