Ofloxacin
Brand Name: Floxin, Ocuflox
Pregnancy Category C
Drug classes: Antibiotic, Fluoroquinolone
Therapeutic actions
Bactericidal; interferes with DNA replication in susceptible gram-positive and gram-negative bacteria, preventing cell reproduction.
Indications
· Lower respiratory tract infections caused by Haemophilus influenzae, Streptococcus pneumoniae
· Acute, uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae, nongonococcal urethritis, and cervicitis due to Chlamydia trachomatis, mixed infections due to both
· Skin and soft tissue infections due to Staphylococcus aureus, Staphylococcus pyogenes, Proteus mirabilis
· Urinary tract infections due to Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa
· Primary treatment of PID (oral)
· Prostatitis due to E. coli
· Treatment of ocular infections caused by susceptible organisms (ophthalmic solution)
· Orphan drug use: treatment of bacterial corneal ulcers
· Otic: otitis externa, chronic suppurative otitis media, acute otitis media
Contraindications
· Contraindicated with allergy to fluoroquinolones, pregnancy, lactation.
Adverse effects
Headache, dizziness, insomnia, fatigue, somnolence, depression, blurred vision,
Nausea, vomiting, dry mouth, diarrhea, abdominal pain, Elevated BUN, AST, ALT, serum creatinine and alkaline phosphatase; decreased WBC, neutrophil count, Hct,
Fever, rash, photosensitivity
Drug Interactions:
· Decreased therapeutic effect with iron salts, zinc, sucralfate
· Decreased absorption with antacids
Nursing considerations
· Arrange for culture and sensitivity tests before beginning therapy.
· Continue therapy for 2 days after the signs of infection have disappeared.
· Administer oral drug 1 hr before or 2 hr after meals with a glass of water.
· Ensure that patient is well hydrated.
· Administer antacids at least 2 hr after dosing.
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